About 30 results found for searched term "5-FAM SE" (0.094 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21711 | 5-FAM SE | Fluorescent Dye |
| 5-Carboxyfluorescein succinimidyl ester | ||
| 5-FAM SE is a green fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates. | ||
| M21715 | 5(6)-FAM SE | Fluorescent Dye |
| 5(6)-Carboxyfluorescein succinimidyl ester mixed isomers | ||
| 5(6)-FAM SE is an amine-reactive green fluorescent dye widely used for labeling proteins or other molecules that contain a primary or secondary aliphatic amine. | ||
| M1801 | KU-55933 | ATM/ATR |
| KU55933 | ||
| KU-55933 is a cell-permeable ATP-competitive inhibitor of ATM (IC50 = 13 nM; Ki = 2.2 nM) with selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 μM for DNAPK, mTOR, PI 3-K, respectively; IC50 > 100 μM for PI 4-K and ATR). | ||
| M3116 | VER 155008 | HSP |
| VER-155008 is a potent inhibitor of the HSP70 family, with IC50 of 0.5 μM and 2.6 μM for HSP70 and Grp78, respectively, exhibits >100-fold selectivity over HSP90. | ||
| M3569 | AST-1306 (TsOH) | EGFR/HER2 |
| AST-6; Allitinib tosylate | ||
| AST-1306 is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases, | ||
| M4843 | SU6656 | Src-bcr-Abl |
| SU-6656 | ||
| SU 6656 is a selective Src family kinase inhibitor with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. | ||
| M5258 | Mivebresib | Epigenetic Reader Domain |
| ABBV-075 | ||
| Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4) | ||
| M6151 | Larotrectinib (LOXO-101) | Trk |
| ARRY-470, larotrectinib | ||
| Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. | ||
| M6175 | Serabelisib | PI3K |
| INK-1117,MLN-1117,TAK-117 | ||
| Serabelisib (INK-1117,MLN-1117,TAK-117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase. | ||
| M6367 | A 419259 trihydrochloride | Src-bcr-Abl |
| RK 20449 trihydrochloride | ||
| A 419259 trihydrochloride is a inhibitor of Src family kinases. | ||
| M6650 | Daminozide | Histone demethylase |
| DaminoDaminozide is a plant growth regulator and selective inhibitor of human KDM2/7 histone demethylases, with IC50 values of 0.55, 1.5, and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively.Daminozide is >100-fold selective for KDM2/7 demethylases compared to other demethylase subfamily members tested. zide is a selective KDM2/7 inhibitor. | ||
| M6968 | ML141 (CID-2950007) | Ras |
| CID-2950007 | ||
| ML141 (CID-2950007) is a selective inhibitor of Cdc42 Rho family GTPase. | ||
| M7536 | BMS-935177 | BTK |
| BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective. | ||
| M8047 | PD173952 | Others |
| PD173952 is a Src family kinase inhibitor. | ||
| M8529 | A-366 | Histone Methyltransferase |
| A366 | ||
| A-366 is a potent and highly selective peptide-competitive inhibitor of histone methyltransferase G9a, with IC50s of 3.3 nM and 38 nM for G9a and GLP, respectively, and is more than 1,000-fold selective for G9a and GLP over 21 other methyltransferases. A-366 is also a potent inhibitor of Spindlin1-H3K4me3 interaction (IC50=182.6 nM).A-366 shows high affinity for human H3R (Ki=17 nM) and exhibits subtype selectivity between subpopulations of the histaminergic and dopaminergic receptor families. It can be used for induction and maintenance of pluripotent stem cells in mice. | ||
| M9664 | TL02-59 | Src-bcr-Abl |
| TL0259 | ||
| TL02-59 is a selective, orally active Src-family kinase Fgr inhibitor with IC50 of 0.03 nM, it also inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. | ||
| M9817 | MLS000532223 | Ras |
| MLS000532223 is a selective inhibitor of Rho family GTPases, with EC50 ranging from 16 μM to 120 μM. | ||
| M9889 | PCI-29732 | BTK |
| PCI29732 | ||
| PCI-29732 is a potent, reversible BTK inhibitor with Kiapp values of 8.2, 4.6, and 2.5 nM for BTK, Lck, and Lyn, respectively, and has only modest inhibitory activity against Itk, another Tec family kinase. In addition, PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP binding site of ABCG2. | ||
| M10768 | SKF83959 | Others |
| SKF83959 is a potent selective dopamine D1-like Receptor partial agonist. SKF83959 Ki to rats D1，D5，D2AND D3 The values are 1.18, 7.56, 920, and 399 nM, respectively. SKF83959 is a potent sigma (σ)-1 receptor allosteric modulator. SKF83959 belongs to the benzazepine family and has an improving effect on cognitive dysfunction. SKF83959 can be used to study Alzheimer's disease and depression. | ||
| M10832 | HPK1-IN-7 | MAPKAPK2/MAP3K/MAP4K |
| HPK1-IN-7 is a potent inhibitor of the orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) (IC50=2.6 nM), with excellent family and kinase group selectivity. The HPK1-IN-7 is selective for IRAK4 (59 nM) and GLK (140 nM). HPK1-IN-7 combined with anti-PD1 has shown powerful efficacy in MC38 cogenic tumor models. | ||
| M10927 | GFB-8438 | TRP Channel |
| GFB-8438 is a potent subtype selective TRPC5 inhibitor against hTRPC5 and hTRPC4 IC50 0.18 and 0.29 μM, respectively. GFB-8438 has good selectivity for TRPC6, other members of the TRP family, NaV1.5, and limited activity against hERG channels. Protective effect of GFB-8438 on mouse podocytes. | ||
| M11149 | Uniconazole | Plant growth regulators |
| Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols. | ||
| M13400 | Recombinant Human UBA5 (E.coli, N-6His) | Recombinant Proteins |
| Ubiquitin-like modifier-activating enzyme 5 | ||
| UBA5 is a member of the ubiquitin activated E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are identified as covalently binding to a variety of cellular substrates through a three-step enzymatic pathway. Ubiquitin activase (E1) plays a crucial role in the first step of activating ubiquitin or ubiquitin-like proteins in the ubiquitination pathway. | ||
| M13536 | VRT-043198 | Caspase |
| VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. | ||
| M13787 | Hoechst 33258 analog | Fluorescent Dye |
| Hoechst 33258 analog are part of a family of blue fluorescent dyes used to stain DNA. | ||
| M13788 | Hoechst 33258 analog 6 | Fluorescent Dye |
| Hoechst 33258 analog 6 is a anglog of Hoechst stains(Hoechst 33258), which are part of a family of blue fluorescent dyes used to stain DNA. | ||
| M14561 | Recombinant Human MIP-5/CCL15 Protein (E. coli, aa 22-113, C-His) | Recombinant Proteins |
| SCYA15; HCC-2; NCC-3 | ||
| Chemokine ligand 15 (CCL15), also known as leukotactin-1, MIP5, MIP1 and HCC-2, is a small cytokine belonging to the C-C chemokine family. CCL15 is prevantly expressed in liver, small intestine, colon, and in certain leukocytes and macrophages of the lung. | ||
| M14911 | CH6953755 | Src-bcr-Abl |
| CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo. | ||
| M21136 | ABD957 | MAGL |
| ABD957 is a potent and selective covalent inhibitor of the ABHD17 family of depalmitoylases, inhibiting IC50 at an IC50 of 0.21 µM. ABD957 impaired N-Ras depalmitylation in AML cells, reducing N-Ras signaling and the growth of NRAS mutant AML cells. | ||
| M21709 | 5-FAM | Fluorescent Dye |
| 5-Carboxyfluorescein | ||
| 5-FAM (5-Carboxyfluorescein) is a green fluorescent reagent used for in situ labeling peptides, proteins and nucleotides. 5-FAM is a single isomer with Ex/Em of 490 nm/520 nm. | ||
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